Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV. Chao CW, Sprouse KR, Miranda MC, Catanzaro NJ, Hubbard ML, Addetia A, Stewart C, Brown JT, Dosey A, Valdez A, Ravichandran R, Hendricks GG, Ahlrichs M, Dobbins C, Hand A, McGowan J, Simmons B, Treichel C, Willoughby I, Walls AC, McGuire AT, Leaf EM, Baric RS, Schäfer A, Veesler D, King NP. Cell Rep. 2024 Dec 6;43(12):115036. doi: 10.1016/j.celrep.2024.115036. PMID: 39644492

Designed miniproteins potently inhibit and protect against MERS-CoV. Ragotte RJ, Alejandra Tortorici M, Catanzaro NJ, Addetia A, Coventry B, Froggatt HM, Lee J, Stewart C, Brown JT, Goreshnik I, Sims JN, Milles LF, Wicky BIM, Glögl M, Gerben S, Kang A, Bera AK, Sharkey W, Schäfer A, Baric RS, Baker D, Veesler D. bioRxiv [Preprint]. 2024 Nov 4:2024.11.03.621760. doi: 10.1101/2024.11.03.621760. PMID: 39574666

Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses. Rexhepaj M, Asarnow D, Perruzza L, Park YJ, Guarino B, Mccallum M, Culap K, Saliba C, Leoni G, Balmelli A, Yoshiyama CN, Dickinson MS, Quispe J, Brown JT, Tortorici MA, Sprouse KR, Taylor AL, Corti D, Starr TN, Benigni F, Veesler D. Immunity. 2024 Oct 30:S1074-7613(24)00481-3. doi: 10.1016/j.immuni.2024.10.001. Online ahead of print.PMID: 39488210

Computational design of prefusion-stabilized Herpesvirus gB trimers. McCallum M, Veesler D. bioRxiv [Preprint]. 2024 Oct 24:2024.10.23.619923. doi: 10.1101/2024.10.23.619923. PMID: 39484573

Design of customized coronavirus receptors. Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H. Nature. 2024 Oct 30. doi: 10.1038/s41586-024-08121-5. Online ahead of print. PMID: 39478224

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification. Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota E Jr, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN. Cell. 2024 Oct 4:S0092-8674(24)01084-5. doi: 10.1016/j.cell.2024.09.026. Online ahead of print.PMID: 39383863

Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens. Miranda MC, Kepl E, Navarro MJ, Chen C, Johnson M, Sprouse KR, Stewart C, Palser A, Valdez A, Pettie D, Sydeman C, Ogohara C, Kraft JC, Pham M, Murphy M, Wrenn S, Fiala B, Ravichandran R, Ellis D, Carter L, Corti D, Kellam P, Lee K, Walls AC, Veesler D, King NP. NPJ Vaccines. 2024 Oct 8;9(1):184. doi: 10.1038/s41541-024-00982-1.PMID: 39379400

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses. Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Xiong Q, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukari A, Starr T, Yan H, Veesler D. bioRxiv [Preprint]. 2024 Aug 28:2024.08.28.608351. doi: 10.1101/2024.08.28.608351.PMID: 39253417

A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variants. Lee J, Case JB, Park YJ, Ravichandran R, Asarnow D, Tortorici MA, Brown JT, Sanapala S, Carter L, Baker D, Diamond MS, Veesler D. bioRxiv [Preprint]. 2024 Aug 10:2024.08.08.606885. doi: 10.1101/2024.08.08.606885.PMID: 39149384

Computationally designed mRNA-launched protein nanoparticle vaccines. Hendricks GG, Grigoryan L, Navarro MJ, Catanzaro NJ, Hubbard ML, Powers JM, Mattocks M, Treichel C, Walls AC, Lee J, Ellis D, Wang JYJ, Cheng S, Miranda MC, Valdez A, Chao CW, Chan S, Men C, Johnson MR, Hui H, Wu SY, Lujan V, Muramatsu H, Lin PJC, Sung MMH, Tam YK, Leaf EM, Pardi N, Baric RS, Pulendran B, Veesler D, Schäfer A, King NP. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604655. doi: 10.1101/2024.07.22.604655.PMID: 39091730

Functional and antigenic landscape of the Nipah virus receptor binding protein. Larsen BB, McMahon T, Brown JT, Wang Z, Radford CE, Crowe JE Jr, Veesler D, Bloom JD. bioRxiv [Preprint]. 2024 Apr 19:2024.04.17.589977. doi: 10.1101/2024.04.17.589977.PMID: 38659959

Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans. Addetia A, Stewart C, Seo AJ, Sprouse KR, Asiri AY, Al-Mozaini M, Memish ZA, Alshukairi AN, Veesler D. Cell Rep. 2024 Jul 24;43(8):114530. doi: 10.1016/j.celrep.2024.114530. Online ahead of print. PMID: 39058596

Broadly neutralizing antibodies against emerging delta-coronaviruses. Rexhepaj M, Park YJ, Perruzza L, Asarnow D, McCallum M, Culap K, Saliba C, Leoni G, Balmeli A, Yoshiyama C, Dickinson MS, Quispe J, Brown JT, Tortorici MA, Sprouse KR, Taylor AL, Starr TN, Corti D, Begnini F, Veesler D. bioRxiv [Preprint]. 2024 Apr 1:2024.03.27.586411. doi: 10.1101/2024.03.27.586411.PMID: 38617231

Local structural flexibility drives oligomorphism in computationally designed protein assemblies. Khmelinskaia A, Bethel NP, Fatehi F, Antanasijevic A, Borst AJ, Lai SH, Wang JYJ, Mallik BB, Miranda MC, Watkins AM, Ogohara C, Caldwell S, Wu M, Heck AJR, Veesler D, Ward AB, Baker D, Twarock R, King NP.bioRxiv. 2023 Oct 19:2023.10.18.562842. doi: 10.1101/2023.10.18.562842. Preprint.PMID: 37905007

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor. McCallum M, Park YJ, Stewart C, Sprouse KR, Addetia A, Brown J, Tortorici MA, Gibson C, Wong E, Ieven M, Telenti A, Veesler D. Cell. 2024 Jun 26:S0092-8674(24)00646-9. doi: 10.1016/j.cell.2024.06.006. Online ahead of print. PMID: 38964328

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades. Dadonaite B, Brown J, McMahon TE, Farrell AG, Figgins MD, Asarnow D, Stewart C, Lee J, Logue J, Bedford T, Murrell B, Chu HY, Veesler D, Bloom JD. Nature. 2024 Jul 3. doi: 10.1038/s41586-024-07636-1. Online ahead of print.PMID: 38961298

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines. Lee J, Stewart C, Schäfer A, Leaf EM, Park YJ, Asarnow D, Powers JM, Treichel C, Sprouse KR, Corti D, Baric R, King NP, Veesler D. Nat Commun. 2024 Jun 28;15(1):5496. doi: 10.1038/s41467-024-49656-5.PMID: 38944664

Streptomyces umbrella toxin particles block hyphal growth of competing species. Zhao Q, Bertolli S, Park YJ, Tan Y, Cutler KJ, Srinivas P, Asfahl KL, Fonesca-García C, Gallagher LA, Li Y, Wang Y, Coleman-Derr D, DiMaio F, Zhang D, Peterson SB, Veesler D, Mougous JD.Nature. 2024 Apr 17. doi: 10.1038/s41586-024-07298-z. Online ahead of print.PMID: 38632398

Structure and design of Langya virus glycoprotein antigens. Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2314990121. doi: 10.1073/pnas.2314990121. Epub 2024 Apr 9.PMID: 38593070

Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates. Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC. Sci Transl Med. 2024 Apr 3;16(741):eadl2055. doi: 10.1126/scitranslmed.adl2055. Epub 2024 Apr 3.PMID: 38569014

Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans. Tortorici MA, Addetia A, Seo AJ, Brown J, Sprouse K, Logue J, Clark E, Franko N, Chu H, Veesler D. Immunity. 2024 Apr 9;57(4):904-911.e4. doi: 10.1016/j.immuni.2024.02.016. Epub 2024 Mar 14.PMID: 38490197

Hierarchical design of pseudosymmetric protein nanoparticles. Dowling QM, Park YJ, Gerstenmaier N, Yang EC, Wargacki A, Hsia Y, Fries CN, Ravichandran R, Walkey C, Burrell A, Veesler D, Baker D, King NP. bioRxiv. 2023 Jun 17:2023.06.16.545393. doi: 10.1101/2023.06.16.545393. Preprint. PMID: 37398374

Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Magaret CA, Li L, deCamp AC, Rolland M, Juraska M, Williamson BD, Ludwig J, Molitor C, Benkeser D, Luedtke A, Simpkins B, Heng F, Sun Y, Carpp LN, Bai H, Dearlove BL, Giorgi EE, Jongeneelen M, Brandenburg B, McCallum M, Bowen JE, Veesler D, Sadoff J, Gray GE, Roels S, Vandebosch A, Stieh DJ, Le Gars M, Vingerhoets J, Grinsztejn B, Goepfert PA, de Sousa LP, Silva MST, Casapia M, Losso MH, Little SJ, Gaur A, Bekker LG, Garrett N, Truyers C, Van Dromme I, Swann E, Marovich MA, Follmann D, Neuzil KM, Corey L, Greninger AL, Roychoudhury P, Hyrien O, Gilbert PB.Nat Commun. 2024 Mar 11;15(1):2175. doi: 10.1038/s41467-024-46536-w.PMID: 38467646

2023

Antigen spacing on protein nanoparticles influences antibody responses to vaccination. Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP. Cell Rep. 2023 Dec 26;42(12):113552. doi: 10.1016/j.celrep.2023.113552. Epub 2023 Dec 13.PMID: 38096058

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus. Lee J, Zepeda SK, Park YJ, Taylor AL, Quispe J, Stewart C, Leaf EM, Treichel C, Corti D, King NP, Starr TN, Veesler D. Cell Host Microbe. 2023 Dec 13;31(12):1961-1973.e11. doi: 10.1016/j.chom.2023.10.018. Epub 2023 Nov 20.PMID: 37989312

Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2. Burke B, Rocha SM, Zhan S, Eckley M, Reasoner C, Addetia A, Lewis J, Fagre A, Charley PA, Richt JA, Weiss SR, Tjalkens RB, Veesler D, Aboellail T, Schountz T. PLoS Pathog. 2023 Oct 19;19(10):e1011728. doi: 10.1371/journal.ppat.1011728. eCollection 2023 Oct.PMID: 37856551

Neutralization, effector function and immune imprinting of Omicron variants. Addetia A, Piccoli L, Case JB, Park YJ, Beltramello M, Guarino B, Dang H, de Melo GD, Pinto D, Sprouse K, Scheaffer SM, Bassi J, Silacci-Fregni C, Muoio F, Dini M, Vincenzetti L, Acosta R, Johnson D, Subramanian S, Saliba C, Giurdanella M, Lombardo G, Leoni G, Culap K, McAlister C, Rajesh A, Dellota E Jr, Zhou J, Farhat N, Bohan D, Noack J, Chen A, Lempp FA, Quispe J, Kergoat L, Larrous F, Cameroni E, Whitener B, Giannini O, Cippà P, Ceschi A, Ferrari P, Franzetti-Pellanda A, Biggiogero M, Garzoni C, Zappi S, Bernasconi L, Kim MJ, Rosen LE, Schnell G, Czudnochowski N, Benigni F, Franko N, Logue JK, Yoshiyama C, Stewart C, Chu H, Bourhy H, Schmid MA, Purcell LA, Snell G, Lanzavecchia A, Diamond MS, Corti D, Veesler D. Nature. 2023 Sep;621(7979):592-601. doi: 10.1038/s41586-023-06487-6. Epub 2023 Aug 30. PMID: 37648855

Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail. Addetia A, Park YJ, Starr T, Greaney AJ, Sprouse KR, Bowen JE, Tiles SW, Van Voorhis WC, Bloom JD, Corti D, Walls AC, Veesler D. Cell Rep. 2023 Jun 27;42(6):112621. doi: 10.1016/j.celrep.2023.112621. Epub 2023 May 26.PMID: 37300832

Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine. Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Kim J, Sprouse KR, Adams LE, Sundaramurthy S, Zhu X, Shirreff LM, Mallory ML, Scobey TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Sci Transl Med. 2023 May 10;15(695):eadg7404. doi: 10.1126/scitranslmed.adg7404. Epub 2023 May 10. PMID: 37163615

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned. O'Connor MA, Hawman DW, Meade-White K, Leventhal S, Song W, Randall S, Archer J, Lewis TB, Brown B, Fredericks MN, Sprouse KR, Tunggal HC, Maughan M, Iwayama N, Ahrens C, Garrison W, Wangari S, Guerriero KA, Hanley P, Lovaglio J, Saturday G, Veesler D, Edlefsen PT, Khandhar AP, Feldmann H, Fuller DH, Erasmus JH. PLoS Pathog. 2023 Apr 19;19(4):e1011298. doi: 10.1371/journal.ppat.1011298. eCollection 2023 Apr. PMID: 37075079.

Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps. Muenks A, Zepeda S, Zhou G, Veesler D, DiMaio F.Nat Commun. 2023 Mar 1;14(1):1164. doi: 10.1038/s41467-023-36732-5. PMID: 36859493

Virus structures and molecular biology exchange glances. Roy P, Veesler D, Rey F. Structure. 2023 Feb 11:S0969-2126(23)00034-5. doi: 10.1016/j.str.2023.01.013. Online ahead of print. PMID: 36841235

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape. Marzi R, Bassi J, Silacci-Fregni C, Bartha I, Muoio F, Culap K, Sprugasci N, Lombardo G, Saliba C, Cameroni E, Cassotta A, Low JS, Walls AC, McCallum M, Tortorici MA, Bowen JE, Dellota EA Jr, Dillen JR, Czudnochowski N, Pertusini L, Terrot T, Lepori V, Tarkowski M, Riva A, Biggiogero M, Franzetti-Pellanda A, Garzoni C, Ferrari P, Ceschi A, Giannini O, Havenar-Daughton C, Telenti A, Arvin A, Virgin HW, Sallusto F, Veesler D, Lanzavecchia A, Corti D, Piccoli L. iScience. 2023 Jan 20;26(1):105726. doi: 10.1016/j.isci.2022.105726. Epub 2022 Dec 5. PMID: 36507220

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H. Nature. 2022 Dec;612(7941):748-757. doi: 10.1038/s41586-022-05513-3. Epub 2022 Dec 7.PMID: 36477529.

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains. Starr TN, Greaney AJ, Stewart CM, Walls AC, Hannon WW, Veesler D, Bloom JD. PLoS Pathog. 2022 Nov 18;18(11):e1010951. doi: 10.1371/journal.ppat.1010951. eCollection 2022 Nov.PMID: 36399443

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines. Bowen JE, Park YJ, Stewart C, Brown JT, Sharkey WK, Walls AC, Joshi A, Sprouse KR, McCallum M, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Nguyen AW, Silva RP, Huang Y, Low JS, Jerak J, Tiles SW, Ahmed K, Shariq A, Dan JM, Zhang Z, Weiskopf D, Sette A, Snell G, Posavad CM, Iqbal NT, Geffner J, Bandera A, Gori A, Sallusto F, Maynard JA, Crotty S, Van Voorhis WC, Simmerling C, Grifantini R, Chu HY, Corti D, Veesler D. Sci Immunol. 2022 Nov 10:eadf1421. doi: 10.1126/sciimmunol.adf1421. Online ahead of print. PMID: 36356052

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Park YJ, Pinto D, Walls AC, Liu Z, De Marco A, Benigni F, Zatta F, Silacci-Fregni C, Bassi J, Sprouse KR, Addetia A, Bowen JE, Stewart C, Giurdanella M, Saliba C, Guarino B, Schmid MA, Franko NM, Logue JK, Dang HV, Hauser K, di Iulio J, Rivera W, Schnell G, Rajesh A, Zhou J, Farhat N, Kaiser H, Montiel-Ruiz M, Noack J, Lempp FA, Janer J, Abdelnabi R, Maes P, Ferrari P, Ceschi A, Giannini O, de Melo GD, Kergoat L, Bourhy H, Neyts J, Soriaga L, Purcell LA, Snell G, Whelan SPJ, Lanzavecchia A, Virgin HW, Piccoli L, Chu HY, Pizzuto MS, Corti D, Veesler D. Science. 2022 Oct 20:eadc9127. doi: 10.1126/science.adc9127. Online ahead of print. PMID: 36264829

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens. Kraft JC, Pham MN, Shehata L, Brinkkemper M, Boyoglu-Barnum S, Sprouse KR, Walls AC, Cheng S, Murphy M, Pettie D, Ahlrichs M, Sydeman C, Johnson M, Blackstone A, Ellis D, Ravichandran R, Fiala B, Wrenn S, Miranda M, Sliepen K, Brouwer PJM, Antanasijevic A, Veesler D, Ward AB, Kanekiyo M, Pepper M, Sanders RW, King NP.Cell Rep Med. 2022 Oct 18;3(10):100780. doi: 10.1016/j.xcrm.2022.100780. Epub 2022 Sep 26.PMID: 36206752

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice. Walls AC, VanBlargan LA, Wu K, Choi A, Navarro MJ, Lee D, Avena L, Berrueta DM, Pham MN, Elbashir S, Kraft JC, Miranda MC, Kepl E, Johnson M, Blackstone A, Sprouse K, Fiala B, O'Connor MA, Brunette N, Arunachalam PS, Shirreff L, Rogers K, Carter L, Fuller DH, Villinger F, Pulendran B, Diamond MS, Edwards DK, King NP, Veesler D. Cell Rep. 2022 Aug 15:111299. doi: 10.1016/j.celrep.2022.111299. Online ahead of print. PMID: 35988541

Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine. Arunachalam PS, Feng Y, Ashraf U, Hu M, Walls AC, Edara VV, Zarnitsyna VI, Aye PP, Golden N, Miranda MC, Green KWM, Threeton BM, Maness NJ, Beddingfield BJ, Bohm RP, Scheuermann SE, Goff K, Dufour J, Russell-Lodrigue K, Kepl E, Fiala B, Wrenn S, Ravichandran R, Ellis D, Carter L, Rogers K, Shirreff LM, Ferrell DE, Deb Adhikary NR, Fontenot J, Hammond HL, Frieman M, Grifoni A, Sette A, O'Hagan DT, Van Der Most R, Rappuoli R, Villinger F, Kleanthous H, Rappaport J, Suthar MS, Veesler D, Wang TT, King NP, Pulendran B. Sci Transl Med. 2022 Aug 17;14(658):eabq4130. doi: 10.1126/scitranslmed.abq4130. Epub 2022 Aug 17. PMID: 35976993

Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial. Song JY, Choi WS, Heo JY, Lee JS, Jung DS, Kim SW, Park KH, Eom JS, Jeong SJ, Lee J, Kwon KT, Choi HJ, Sohn JW, Kim YK, Noh JY, Kim WJ, Roman F, Ceregido MA, Solmi F, Philippot A, Walls AC, Carter L, Veesler D, King NP, Kim H, Ryu JH, Lee SJ, Park YW, Park HK, Cheong HJ. EClinicalMedicine. 2022 Jul 22;51:101569. doi: 10.1016/j.eclinm.2022.101569. eCollection 2022 Sep.PMID: 35879941

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies. Low JS, Jerak J, Tortorici MA, McCallum M, Pinto D, Cassotta A, Foglierini M, Mele F, Abdelnabi R, Weynand B, Noack J, Montiel-Ruiz M, Bianchi S, Benigni F, Sprugasci N, Joshi A, Bowen JE, Stewart C, Rexhepaj M, Walls AC, Jarrossay D, Morone D, Paparoditis P, Garzoni C, Ferrari P, Ceschi A, Neyts J, Purcell LA, Snell G, Corti D, Lanzavecchia A, Veesler D, Sallusto F. Science. 2022 Jul 12:eabq2679. doi: 10.1126/science.abq2679. Online ahead of print. PMID: 35857703

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines. Bowen JE, Addetia A, Dang HV, Stewart C, Brown JT, Sharkey WK, Sprouse KR, Walls AC, Mazzitelli IG, Logue JK, Franko NM, Czudnochowski N, Powell AE, Dellota E Jr, Ahmed K, Ansari AS, Cameroni E, Gori A, Bandera A, Posavad CM, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Iqbal NT, Corti D, Geffner J, Snell G, Grifantini R, Chu HY, Veesler D. Science. 2022 Aug 19;377(6608):890-894. doi: 10.1126/science.abq0203. Epub 2022 Jul 19.PMID: 35857529

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution. Starr TN, Greaney AJ, Hannon WW, Loes AN, Hauser K, Dillen JR, Ferri E, Farrell AG, Dadonaite B, McCallum M, Matreyek KA, Corti D, Veesler D, Snell G, Bloom JD. Science. 2022 Jul 22;377(6604):420-424. doi: 10.1126/science.abo7896. Epub 2022 Jun 28.PMID: 35762884

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge. Malhi H, Homad LJ, Wan YH, Poudel B, Fiala B, Borst AJ, Wang JY, Walkey C, Price J, Wall A, Singh S, Moodie Z, Carter L, Handa S, Correnti CE, Stoddard BL, Veesler D, Pancera M, Olson J, King NP, McGuire AT. Cell Rep Med. 2022 Jun 21;3(6):100658. doi: 10.1016/j.xcrm.2022.100658. Epub 2022 Jun 14. PMID: 35705092 

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Tortorici MA, Walls AC, Joshi A, Park YJ, Eguia RT, Miranda MC, Kepl E, Dosey A, Stevens-Ayers T, Boeckh MJ, Telenti A, Lanzavecchia A, King NP, Corti D, Bloom JD, Veesler D. Cell. 2022 Jun 23;185(13):2279-2291.e17. doi: 10.1016/j.cell.2022.05.019. Epub 2022 May 27. PMID: 35700730

Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant. Wang Z, Dang HV, Amaya M, Xu Y, Yin R, Yan L, Hickey AC, Annand EJ, Horsburgh BA, Reid PA, Smith I, Eden JS, Xu K, Broder CC, Veesler D. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2122769119. doi: 10.1073/pnas.2122769119. Epub 2022 May 26. PMID: 35617431

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice. Grigoryan L, Lee A, Walls AC, Lai L, Franco B, Arunachalam PS, Feng Y, Luo W, Vanderheiden A, Floyd K, Wrenn S, Pettie D, Miranda MC, Kepl E, Ravichandran R, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, Coffman RL, Novack D, Kleanthous H, O'Hagan DT, van der Most R, McLellan JS, Suthar M, Veesler D, King NP, Pulendran B. NPJ Vaccines. 2022 May 23;7(1):55. doi: 10.1038/s41541-022-00472-2.PMID: 35606518

Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants. Zhang JZ, Yeh HW, Walls AC, Wicky BIM, Sprouse KR, VanBlargan LA, Treger R, Quijano-Rubio A, Pham MN, Kraft JC, Haydon IC, Yang W, DeWitt M, Bowen JE, Chow CM, Carter L, Ravichandran R, Wener MH, Stewart L, Veesler D, Diamond MS, Greninger AL, Koelle DM, Baker D. Nat Biotechnol. 2022 Apr 28. doi: 10.1038/s41587-022-01280-8. Online ahead of print. PMID: 35484405

Computational design of mechanically coupled axle-rotor protein assemblies. Courbet A, Hansen J, Hsia Y, Bethel N, Park YJ, Xu C, Moyer A, Boyken SE, Ueda G, Nattermann U, Nagarajan D, Silva DA, Sheffler W, Quispe J, Nord A, King N, Bradley P, Veesler D, Kollman J, Baker D. Science. 2022 Apr 22;376(6591):383-390. doi: 10.1126/science.abm1183. Epub 2022 Apr 21. PMID: 35446645

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetič A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale M Jr, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. Epub 2022 May 25.PMID: 35412328

Structure-based design of stabilized recombinant influenza neuraminidase tetramers. Ellis D, Lederhofer J, Acton OJ, Tsybovsky Y, Kephart S, Yap C, Gillespie RA, Creanga A, Olshefsky A, Stephens T, Pettie D, Murphy M, Sydeman C, Ahlrichs M, Chan S, Borst AJ, Park YJ, Lee KK, Graham BS, Veesler D, King NP, Kanekiyo M. Nat Commun. 2022 Apr 5;13(1):1825. doi: 10.1038/s41467-022-29416-z. PMID: 35383176

Architecture and antigenicity of the Nipah virus attachment glycoprotein. Wang Z, Amaya M, Addetia A, Dang HV, Reggiano G, Yan L, Hickey AC, DiMaio F, Broder CC, Veesler D. Science. 2022 Mar 25;375(6587):1373-1378. doi: 10.1126/science.abm5561. Epub 2022 Mar 3. PMID: 35239409.

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy. Greaney AJ, Starr TN, Eguia RT, Loes AN, Khan K, Karim F, Cele S, Bowen JE, Logue JK, Corti D, Veesler D, Chu HY, Sigal A, Bloom JD.PLoS Pathog. 2022 Feb 8;18(2):e1010248. doi: 10.1371/journal.ppat.1010248. eCollection 2022 Feb. PMID: 35134084

SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses. Walls AC*, Sprouse KR, Bowen JE, Joshi A, Franko N, Navarro MJ, Stewart C, Cameroni E, McCallum M, Goecker EA, Degli-Angeli EJ, Logue J, Greninger A, Corti D, Chu HY, Veesler D*. Cell. 2022 Mar 3;185(5):872-880.e3. doi: 10.1016/j.cell.2022.01.011. Epub 2022 Jan 20. PMID: 35123650

ACE2 binding is an ancestral and evolvable trait of sarbecoviruses. Starr TN*, Zepeda SK, Walls AC, Greaney AJ, Alkhovsky S, Veesler D*, Bloom JD*. Nature. 2022 Feb 3. doi: 10.1038/s41586-022-04464-z. Online ahead of print. PMID: 35114688

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Meng B, Abdullahi A, Ferreira IATM, Goonawardane N, Saito A, Kimura I, Yamasoba D, Gerber PP, Fatihi S, Rathore S, Zepeda SK, Papa G, Kemp SA, Ikeda T, Toyoda M, Tan TS, Kuramochi J, Mitsunaga S, Ueno T, Shirakawa K, Takaori-Kondo A, Brevini T, Mallery DL, Charles OJ; CITIID-NIHR BioResource COVID- Collaboration; Genotype to Phenotype Japan (GP-Japan) Consortium members; Ecuador-COVID19 Consortium, Bowen JE, Joshi A, Walls AC, Jackson L, Martin D, Smith KGC, Bradley J, Briggs JAG, Choi J, Madissoon E, Meyer K, Mlcochova P, Ceron-Gutierrez L, Doffinger R, Teichmann SA, Fisher AJ, Pizzuto MS, de Marco A, Corti D, Hosmillo M, Lee JH, James LC, Thukral L, Veesler D, Sigal A, Sampaziotis F, Goodfellow IG, Matheson NJ, Sato K, Gupta RK. Nature. 2022 Feb 1. doi: 10.1038/s41586-022-04474-x. Online ahead of print. PMID: 35104837

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. McCallum M, Czudnochowski N, Rosen LE, Zepeda SK, Bowen JE, Walls AC, Hauser K, Joshi A, Stewart C, Dillen JR, Powell AE, Croll TI, Nix J, Virgin HW, Corti D, Snell G*, Veesler D*. Science. 2022 Feb 25;375(6583):864-868. doi: 10.1126/science.abn8652. Epub 2022 Jan 25. PMID: 35076256

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift. Cameroni E, Bowen JE, Rosen LE, Saliba C, Zepeda SK, Culap K, Pinto D, VanBlargan LA, De Marco A, di Iulio J, Zatta F, Kaiser H, Noack J, Farhat N, Czudnochowski N, Havenar-Daughton C, Sprouse KR, Dillen JR, Powell AE, Chen A, Maher C, Yin L, Sun D, Soriaga L, Bassi J, Silacci-Fregni C, Gustafsson C, Franko NM, Logue J, Iqbal NT, Mazzitelli I, Geffner J, Grifantini R, Chu H, Gori A, Riva A, Giannini O, Ceschi A, Ferrari P, Cippà PE, Franzetti-Pellanda A, Garzoni C, Halfmann PJ, Kawaoka Y, Hebner C, Purcell LA, Piccoli L, Pizzuto MS, Walls AC, Diamond MS, Telenti A, Virgin HW, Lanzavecchia A, Snell G*, Veesler D*, Corti D*. Nature. 2021 Dec 23. doi: 10.1038/s41586-021-04386-2. Online ahead of print. PMID: 35016195

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry. Park YJ, De Marco A, Starr TN, Liu Z, Pinto D, Walls AC, Zatta F, Zepeda SK, Bowen JE, Sprouse KR, Joshi A, Giurdanella M, Guarino B, Noack J, Abdelnabi R, Foo SC, Rosen LE, Lempp FA, Benigni F, Snell G, Neyts J, Whelan SPJ, Virgin HW, Bloom JD, Corti D, Pizzuto MS, Veesler D. Science. 2022 Jan 28;375(6579):449-454. doi: 10.1126/science.abm8143. Epub 2022 Jan 6. PMID: 34990214

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants. McCallum M, Walls AC, Sprouse KR, Bowen JE, Rosen LE, Dang HV, De Marco A, Franko N, Tilles SW, Logue J, Miranda MC, Ahlrichs M, Carter L, Snell G, Pizzuto MS, Chu HY, Van Voorhis WC, Corti D, Veesler D. Science. 2021 Dec 24;374(6575):1621-1626. doi: 10.1126/science.abl8506. Epub 2021 Nov 9. PMID: 34751595

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines. Walls AC, Miranda MC, Schäfer A, Pham MN, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shirreff L, Ferrell DE, Bowen J, Brunette N, Kepl E, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Sprouse KR, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, Leist SR, Martinez DR, Clark M, Tisch R, O'Hagan DT, Van Der Most R, Van Voorhis WC, Corti D, McLellan JS, Kleanthous H, Sheahan TP, Smith KD, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric RS, King NP*, Veesler D*. Cell. 2021 Oct 14;184(21):5432-5447.e16. doi: 10.1016/j.cell.2021.09.015. Epub 2021 Sep 15. PMID: 34619077

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies. Lempp FA, Soriaga L, Montiel-Ruiz M, Benigni F, Noack J, Park YJ, Bianchi S, Walls AC, Bowen JE, Zhou J, Kaiser H, Joshi A, Agostini M, Meury M, Dellota E Jr, Jaconi S, Cameroni E, Martinez-Picado J, Vergara-Alert J, Izquierdo-Useros N, Virgin HW, Lanzavecchia A, Veesler D, Purcell L, Telenti A, Corti D. Nature. 2021 Aug 31. doi: 10.1038/s41586-021-03925-1. Online ahead of print.PMID: 34464958

Tackling COVID-19 with neutralizing monoclonal antibodies. Corti D, Purcell LA, Snell G, Veesler D. Cell. 2021 Aug 19;184(17):4593-4595. doi: 10.1016/j.cell.2021.07.027.PMID: 34416148

Broad betacoronavirus neutralization by a stem helix-specific human antibody. Pinto D, Sauer MM, Czudnochowski N, Low JS, Tortorici MA, Housley MP, Noack J, Walls AC, Bowen JE, Guarino B, Rosen LE, di Iulio J, Jerak J, Kaiser H, Islam S, Jaconi S, Sprugasci N, Culap K, Abdelnabi R, Foo C, Coelmont L, Bartha I, Bianchi S, Silacci-Fregni C, Bassi J, Marzi R, Vetti E, Cassotta A, Ceschi A, Ferrari P, Cippà PE, Giannini O, Ceruti S, Garzoni C, Riva A, Benigni F, Cameroni E, Piccoli L, Pizzuto MS, Smithey M, Hong D, Telenti A, Lempp FA, Neyts J, Havenar-Daughton C, Lanzavecchia A, Sallusto F, Snell G, Virgin HW, Beltramello M, Corti D*, Veesler D*. Science. 2021 Sep 3;373(6559):1109-1116. doi: 10.1126/science.abj3321. Epub 2021 Aug 6. PMID: 34344823

Discovery and characterization of spike N-terminal domain-binding aptamers for rapid SARS-CoV-2 detection. Kacherovsky N, Yang LF, Dang HV, Cheng EL, Cardle II, Walls AC, McCallum M, Sellers DL, DiMaio F, Salipante SJ, Corti D, Veesler D*, Pun S*. Angew Chem Int Ed Engl. 2021 Jul 30. doi: 10.1002/anie.202107730. Online ahead of print. PMID: 34328683

Broad sarbecovirus neutralization by a human monoclonal antibody. Tortorici MA, Czudnochowski N, Starr TN, Marzi R, Walls AC, Zatta F, Bowen JE, Jaconi S, Di Iulio J, Wang Z, De Marco A, Zepeda SK, Pinto D, Liu Z, Beltramello M, Bartha I, Housley MP, Lempp FA, Rosen LE, Dellota E Jr, Kaiser H, Montiel-Ruiz M, Zhou J, Addetia A, Guarino B, Culap K, Sprugasci N, Saliba C, Vetti E, Giacchetto-Sasselli I, Fregni CS, Abdelnabi R, Foo SC, Havenar-Daughton C, Schmid MA, Benigni F, Cameroni E, Neyts J, Telenti A, Virgin HW, Whelan SPJ, Snell G, Bloom JD, Corti D*, Veesler D*, Pizzuto MS*. Nature. 2021 Sep;597(7874):103-108. doi: 10.1038/s41586-021-03817-4. Epub 2021 Jul 19.

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design. Ellis D, Brunette N, Crawford KHD, Walls AC, Pham MN, Chen C, Herpoldt KL, Fiala B, Murphy M, Pettie D, Kraft JC, Malone KD, Navarro MJ, Ogohara C, Kepl E, Ravichandran R, Sydeman C, Ahlrichs M, Johnson M, Blackstone A, Carter L, Starr TN, Greaney AJ, Lee KK, Veesler D, Bloom JD, King NP. Front Immunol. 2021 Jun 29;12:710263. doi: 10.3389/fimmu.2021.710263. eCollection 2021. PMID: 34267764

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Starr TN, Czudnochowski N, Liu Z, Zatta F, Park YJ, Addetia A, Pinto D, Beltramello M, Hernandez P, Greaney AJ, Marzi R, Glass WG, Zhang I, Dingens AS, Bowen JE, Tortorici MA, Walls AC, Wojcechowskyj JA, De Marco A, Rosen LE, Zhou J, Montiel-Ruiz M, Kaiser H, Dillen J, Tucker H, Bassi J, Silacci-Fregni C, Housley MP, di Iulio J, Lombardo G, Agostini M, Sprugasci N, Culap K, Jaconi S, Meury M, Dellota E, Abdelnabi R, Foo SC, Cameroni E, Stumpf S, Croll TI, Nix JC, Havenar-Daughton C, Piccoli L, Benigni F, Neyts J, Telenti A, Lempp FA, Pizzuto MS, Chodera JD, Hebner CM, Virgin HW, Whelan SPJ, Veesler D, Corti D, Bloom JD, Snell G. Nature. 2021 Jul 14. doi: 10.1038/s41586-021-03807-6. Online ahead of print. PMID: 34261126

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern. McCallum M, Bassi J, De Marco A, Chen A, Walls AC, Di Iulio J, Tortorici MA, Navarro MJ, Silacci-Fregni C, Saliba C, Sprouse KR, Agostini M, Pinto D, Culap K, Bianchi S, Jaconi S, Cameroni E, Bowen JE, Tilles SW, Pizzuto MS, Guastalla SB, Bona G, Pellanda AF, Garzoni C, Van Voorhis WC, Rosen LE, Snell G, Telenti A, Virgin HW, Piccoli L*, Corti D*, Veesler D*. Science. 2021 Jul 1:eabi7994. doi: 10.1126/science.abi7994. Online ahead of print. PMID: 34210893

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020. Hodcroft EB, Zuber M, Nadeau S, Vaughan TG, Crawford KHD, Althaus CL, Reichmuth ML, Bowen JE, Walls AC, Corti D, Bloom JD, Veesler D, Mateo D, Hernando A, Comas I, González-Candelas F; SeqCOVID-SPAIN consortium, Stadler T, Neher RA. Nature. 2021 Jul;595(7869):707-712. doi: 10.1038/s41586-021-03677-y. Epub 2021 Jun 7. PMID: 34098568

Generation of ordered protein assemblies using rigid three-body fusion. Vulovic I, Yao Q, Park YJ, Courbet A, Norris A, Busch F, Sahasrabuddhe A, Merten H, Sahtoe DD, Ueda G, Fallas JA, Weaver SJ, Hsia Y, Langan RA, Plückthun A, Wysocki VH, Veesler D, Jensen GJ, Baker D. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2015037118. doi: 10.1073/pnas.2015037118. PMID: 34074752

Structural basis for broad coronavirus neutralization. Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D. Nat Struct Mol Biol. 2021 Jun;28(6):478-486. doi: 10.1038/s41594-021-00596-4. Epub 2021 May 12. PMID: 33981021

Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins. Dang HV, Cross RW, Borisevich V, Bornholdt ZA, West BR, Chan YP, Mire CE, Da Silva SC, Dimitrov AS, Yan L, Amaya M, Navaratnarajah CK, Zeitlin L, Geisbert TW, Broder CC, Veesler D. Nat Struct Mol Biol. 2021 May;28(5):426-434. doi: 10.1038/s41594-021-00584-8. Epub 2021 Apr 29. PMID: 33927387

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity. Arunachalam PS, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Röltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Spencer S, Doyle-Meyers L, Bohm RP, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O'Hagan DT, Van Der Most R, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar MS, King NP, Veesler D, Pulendran B. Nature. 2021 Jun;594(7862):253-258. doi: 10.1038/s41586-021-03530-2. Epub 2021 Apr 19. PMID: 33873199

Design of multi-scale protein complexes by hierarchical building block fusion. Hsia Y, Mout R, Sheffler W, Edman NI, Vulovic I, Park YJ, Redler RL, Bick MJ, Bera AK, Courbet A, Kang A, Brunette TJ, Nattermann U, Tsai E, Saleem A, Chow CM, Ekiert D, Bhabha G, Veesler D, Baker D. Nat Commun. 2021 Apr 16;12(1):2294. doi: 10.1038/s41467-021-22276-z. PMID: 33863889

Functional Analysis of the Fusion and Attachment Glycoproteins of Mojiang Henipavirus. Cheliout Da Silva S, Yan L, Dang HV, Xu K, Epstein JH, Veesler D, Broder CC. Viruses. 2021 Mar 22;13(3):517. doi: 10.3390/v13030517. PMID: 33809833

Designed proteins assemble antibodies into modular nanocages. Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, Etemadi A, Fahning ML, Lazarovits J, Roederer A, Walls AC, Stewart L, Mazloomi M, King NP, Campbell DJ, McGuire AT, Stamatatos L, Ruohola-Baker H, Mathieu J, Veesler D, Baker D. Science. 2021 Apr 2;372(6537):eabd9994. doi: 10.1126/science.abd9994. PMID: 33795432

Quadrivalent influenza nanoparticle vaccines induce broad protection. Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M. Nature. 2021 Apr;592(7855):623-628. doi: 10.1038/s41586-021-03365-x. Epub 2021 Mar 24. PMID: 33762730

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D*, Pizzuto MS*, Veesler D*. Cell. 2021 Apr 29;184(9):2332-2347.e16. doi: 10.1016/j.cell.2021.03.028. Epub 2021 Mar 16. PMID: 33761326

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, Bianchi S, Tortorici MA, Bowen J, Culap K, Jaconi S, Cameroni E, Snell G, Pizzuto MS, Pellanda AF, Garzoni C, Riva A; CITIID-NIHR BioResource COVID-19 Collaboration, Elmer A, Kingston N, Graves B, McCoy LE, Smith KGC, Bradley JR, Temperton N, Ceron-Gutierrez L, Barcenas-Morales G; COVID-19 Genomics UK (COG-UK) Consortium, Harvey W, Virgin HW, Lanzavecchia A, Piccoli L, Doffinger R, Wills M, Veesler D, Corti D, Gupta RK. Nature. 2021 May;593(7857):136-141. doi: 10.1038/s41586-021-03412-7. Epub 2021 Mar 11. PMID: 33706364

In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19.Phan IQ, Subramanian S, Kim D, Murphy M, Pettie D, Carter L, Anishchenko I, Barrett LK, Craig J, Tillery L, Shek R, Harrington WE, Koelle DM, Wald A, Veesler D, King N, Boonyaratanakornkit J, Isoherranen N, Greninger AL, Jerome KR, Chu H, Staker B, Stewart L, Myler PJ, Van Voorhis WC.Sci Rep. 2021 Feb 22;11(1):4290. doi: 10.1038/s41598-021-83730-y. PMID: 33619344

Structural biology in the fight against COVID-19. Bárcena M, Barnes CO, Beck M, Bjorkman PJ, Canard B, Gao GF, Gao Y, Hilgenfeld R, Hummer G, Patwardhan A, Santoni G, Saphire EO, Schaffitzel C, Schendel SL, Smith JL, Thorn A, Veesler D, Zhang P, Zhou Q. Nat Struct Mol Biol. 2021 Jan;28(1):2-7. doi: 10.1038/s41594-020-00544-8. PMID: 33437043

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Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2. Walls AC, Fiala B, Schäfer A, Wrenn S, Pham MN, Murphy M, Tse LV, Shehata L, O'Connor MA, Chen C, Navarro MJ, Miranda MC, Pettie D, Ravichandran R, Kraft JC, Ogohara C, Palser A, Chalk S, Lee EC, Guerriero K, Kepl E, Chow CM, Sydeman C, Hodge EA, Brown B, Fuller JT, Dinnon KH 3rd, Gralinski LE, Leist SR, Gully KL, Lewis TB, Guttman M, Chu HY, Lee KK, Fuller DH, Baric RS, Kellam P, Carter L, Pepper M, Sheahan TP, Veesler D*, King NP*. Cell. 2020 Nov 25;183(5):1367-1382.e17. doi: 10.1016/j.cell.2020.10.043. Epub 2020 Oct 31. PMID: 33160446

HIV-1 VRC01 Germline-Targeting Immunogens Select Distinct Epitope-Specific B Cell Receptors. Lin YR, Parks KR, Weidle C, Naidu AS, Khechaduri A, Riker AO, Takushi B, Chun JH, Borst AJ, Veesler D, Stuart A, Agrawal P, Gray M, Pancera M, Huang PS, Stamatatos L. Immunity. 2020 Oct 13;53(4):840-851.e6. doi: 10.1016/j.immuni.2020.09.007. PMID: 33053332

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology. Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D*, Veesler D*. Cell. 2020 Nov 12;183(4):1024-1042.e21. doi: 10.1016/j.cell.2020.09.037. Epub 2020 Sep 16. PMID: 32991844

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Tortorici MA, Beltramello M, Lempp FA, Pinto D, Dang HV, Rosen LE, McCallum M, Bowen J, Minola A, Jaconi S, Zatta F, De Marco A, Guarino B, Bianchi S, Lauron EJ, Tucker H, Zhou J, Peter A, Havenar-Daughton C, Wojcechowskyj JA, Case JB, Chen RE, Kaiser H, Montiel-Ruiz M, Meury M, Czudnochowski N, Spreafico R, Dillen J, Ng C, Sprugasci N, Culap K, Benigni F, Abdelnabi R, Foo SC, Schmid MA, Cameroni E, Riva A, Gabrieli A, Galli M, Pizzuto MS, Neyts J, Diamond MS, Virgin HW, Snell G, Corti D, Fink K*, Veesler D*. Science. 2020 Nov 20;370(6519):950-957. doi: 10.1126/science.abe3354. Epub 2020 Sep 24. PMID: 32972994

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. Science. 2020 Oct 23;370(6515):426-431. doi: 10.1126/science.abd9909. Epub 2020 Sep 9. PMID: 32907861

Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak. Dingens AS, Crawford KHD, Adler A, Steele SL, Lacombe K, Eguia R, Amanat F, Walls AC, Wolf CR, Murphy M, Pettie D, Carter L, Qin X, King NP, Veesler D, Krammer F, Dickerson JA, Chu HY, Englund JA, Bloom JD. Nat Commun. 2020 Sep 1;11(1):4378. doi: 10.1038/s41467-020-18178-1. PMID: 32873791

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding. Starr TN, Greaney AJ, Hilton SK, Ellis D, Crawford KHD, Dingens AS, Navarro MJ, Bowen JE, Tortorici MA, Walls AC, King NP, Veesler D, Bloom JD. Cell. 2020 Sep 3;182(5):1295-1310.e20. doi: 10.1016/j.cell.2020.08.012. Epub 2020 Aug 11. PMID: 32841599

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation. McCallum M, Walls AC, Bowen JE, Corti D, Veesler D. Nat Struct Mol Biol. 2020 Oct;27(10):942-949. doi: 10.1038/s41594-020-0483-8. Epub 2020 Aug 4. PMID: 32753755

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens. Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, Zwart PH, Veesler D, Kanekiyo M, Graham BS, Sanders RW, Moore JP, Klasse PJ, Ward AB, King NP, Baker D. Elife. 2020 Aug 4;9:e57659. doi: 10.7554/eLife.57659. PMID: 32748788

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates. Erasmus JH, Khandhar AP, O'Connor MA, Walls AC, Hemann EA, Murapa P, Archer J, Leventhal S, Fuller JT, Lewis TB, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH. Sci Transl Med. 2020 Aug 5;12(555):eabc9396. doi: 10.1126/scitranslmed.abc9396. Epub 2020 Jul 20. PMID: 32690628

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Pinto D, Park YJ, Beltramello M, Walls AC, Tortorici MA, Bianchi S, Jaconi S, Culap K, Zatta F, De Marco A, Peter A, Guarino B, Spreafico R, Cameroni E, Case JB, Chen RE, Havenar-Daughton C, Snell G, Telenti A, Virgin HW, Lanzavecchia A, Diamond MS, Fink K, Veesler D*, Corti D*. Nature. 2020 Jul;583(7815):290-295. doi: 10.1038/s41586-020-2349-y. Epub 2020 May 18. PMID: 32422645

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays. Crawford KHD, Eguia R, Dingens AS, Loes AN, Malone KD, Wolf CR, Chu HY, Tortorici MA, Veesler D, Murphy M, Pettie D, King NP, Balazs AB, Bloom JD. Viruses. 2020 May 6;12(5):513. doi: 10.3390/v12050513. PMID: 32384820

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Cell. 2020 Apr 16;181(2):281-292.e6. doi: 10.1016/j.cell.2020.02.058. Epub 2020 Mar 9. PMID: 32155444

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Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.Parks KR, MacCamy AJ, Trichka J, Gray M, Weidle C, Borst AJ, Khechaduri A, Takushi B, Agrawal P, Guenaga J, Wyatt RT, Coler R, Seaman M, LaBranche C, Montefiori DC, Veesler D, Pancera M, McGuire A, Stamatatos L. Cell Rep. 2019 Dec 3;29(10):3060-3072.e7. doi: 10.1016/j.celrep.2019.10.071. PMID: 31801073

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D. Nat Struct Mol Biol. 2019 Dec;26(12):1151-1157. doi: 10.1038/s41594-019-0334-7. Epub 2019 Dec 2. PMID: 31792450

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection. Mire CE, Chan YP, Borisevich V, Cross RW, Yan L, Agans KN, Dang HV, Veesler D, Fenton KA, Geisbert TW, Broder CC.J Infect Dis. 2020 May 11;221(Suppl 4):S471-S479. doi: 10.1093/infdis/jiz515. PMID: 31686101

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections. Dang HV, Chan YP, Park YJ, Snijder J, Da Silva SC, Vu B, Yan L, Feng YR, Rockx B, Geisbert TW, Mire CE, Broder CC, Veesler D. Nat Struct Mol Biol. 2019 Oct;26(10):980-987. doi: 10.1038/s41594-019-0308-9. Epub 2019 Sep 30. PMID: 31570878

Structural insights into coronavirus entry. Tortorici MA, Veesler D. Adv Virus Res. 2019;105:93-116. doi: 10.1016/bs.aivir.2019.08.002. Epub 2019 Aug 22. PMID: 31522710

Structural basis for human coronavirus attachment to sialic acid receptors. Tortorici MA, Walls AC, Lang Y, Wang C, Li Z, Koerhuis D, Boons GJ, Bosch BJ, Rey FA, de Groot RJ, Veesler D. Nat Struct Mol Biol. 2019 Jun;26(6):481-489. doi: 10.1038/s41594-019-0233-y. Epub 2019 Jun 3. PMID: 31160783

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Loré K, Perez L, King NP. Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046. PMID: 30849373

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion. Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D. Cell. 2019 Feb 21;176(5):1026-1039.e15. doi: 10.1016/j.cell.2018.12.028. Epub 2019 Jan 31. PMID: 30712865

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Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy. Park YJ, Lacourse KD, Cambillau C, DiMaio F, Mougous JD, Veesler D. Nat Commun. 2018 Dec 19;9(1):5385. doi: 10.1038/s41467-018-07796-5. PMID: 30568167

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core. Borst AJ, Weidle CE, Gray MD, Frenz B, Snijder J, Joyce MG, Georgiev IS, Stewart-Jones GB, Kwong PD, McGuire AT, DiMaio F, Stamatatos L, Pancera M, Veesler D. Elife. 2018 Nov 7;7:e37688. doi: 10.7554/eLife.37688. PMID: 30403372

Automatically Fixing Errors in Glycoprotein Structures with Rosetta. Frenz B, Rämisch S, Borst AJ, Walls AC, Adolf-Bryfogle J, Schief WR, Veesler D, DiMaio F. Structure. 2019 Jan 2;27(1):134-139.e3. doi: 10.1016/j.str.2018.09.006. Epub 2018 Oct 18. PMID: 30344107

Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins. Ting SY, Bosch DE, Mangiameli SM, Radey MC, Huang S, Park YJ, Kelly KA, Filip SK, Goo YA, Eng JK, Allaire M, Veesler D, Wiggins PA, Peterson SB, Mougous JD. Cell. 2018 Nov 15;175(5):1380-1392.e14. doi: 10.1016/j.cell.2018.09.037. Epub 2018 Oct 18. PMID: 30343895

An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus. Snijder J, Ortego MS, Weidle C, Stuart AB, Gray MD, McElrath MJ, Pancera M, Veesler D, McGuire AT. Immunity. 2018 Apr 17;48(4):799-811.e9. doi: 10.1016/j.immuni.2018.03.026. PMID: 29669253

Allosteric effects in bacteriophage HK97 procapsids revealed directly from covariance analysis of cryo EM data. Xu N, Veesler D, Doerschuk PC, Johnson JE. J Struct Biol. 2018 May;202(2):129-141. doi: 10.1016/j.jsb.2017.12.013. Epub 2018 Jan 10. PMID: 29331608

Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections. Xiong X, Tortorici MA, Snijder J, Yoshioka C, Walls AC, Li W, McGuire AT, Rey FA, Bosch BJ, Veesler D. J Virol. 2018 Jan 30;92(4):e01628-17. doi: 10.1128/JVI.01628-17. Print 2018 Feb 15. PMID: 29093093

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Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Walls AC, Tortorici MA, Snijder J, Xiong X, Bosch BJ, Rey FA, Veesler D. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11157-11162. doi: 10.1073/pnas.1708727114. Epub 2017 Oct 3. PMID: 29073020

The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance. Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D. Structure. 2017 Nov 7;25(11):1732-1739.e5. doi: 10.1016/j.str.2017.09.007. Epub 2017 Oct 12. PMID: 29033288

Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Elife. 2017 Oct 2;6:e30872. doi: 10.7554/eLife.30872. PMID: 28967377

RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps. Frenz B, Walls AC, Egelman EH, Veesler D, DiMaio F. Nat Methods. 2017 Aug;14(8):797-800. doi: 10.1038/nmeth.4340. Epub 2017 Jun 19. PMID: 28628127

Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses. Yu X, Veesler D, Campbell MG, Barry ME, Asturias FJ, Barry MA, Reddy VS. Sci Adv. 2017 May 10;3(5):e1602670. doi: 10.1126/sciadv.1602670. eCollection 2017 May. PMID: 28508067

CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel. James ZM, Borst AJ, Haitin Y, Frenz B, DiMaio F, Zagotta WN, Veesler D. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4430-4435. doi: 10.1073/pnas.1700248114. Epub 2017 Apr 10. PMID: 28396445

Vitrification after multiple rounds of sample application and blotting improves particle density on cryo-electron microscopy grids. Snijder J, Borst AJ, Dosey A, Walls AC, Burrell A, Reddy VS, Kollman JM, Veesler D. J Struct Biol. 2017 Apr;198(1):38-42. doi: 10.1016/j.jsb.2017.02.008. Epub 2017 Feb 22. PMID: 28254381

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Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Eshraghi A, Kim J, Walls AC, Ledvina HE, Miller CN, Ramsey KM, Whitney JC, Radey MC, Peterson SB, Ruhland BR, Tran BQ, Goo YA, Goodlett DR, Dove SL, Celli J, Veesler D, Mougous JD.Cell Host Microbe. 2016 Nov 9;20(5):573-583. doi: 10.1016/j.chom.2016.10.008.PMID: 27832588

Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy. Walls A, Tortorici MA, Bosch BJ, Frenz B, Rottier PJ, DiMaio F, Rey FA, Veesler D. Protein Sci. 2017 Jan;26(1):113-121. doi: 10.1002/pro.3048. Epub 2016 Oct 18. PMID: 27667334

Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy. Walls AC, Tortorici MA, Frenz B, Snijder J, Li W, Rey FA, DiMaio F, Bosch BJ, Veesler D. Nat Struct Mol Biol. 2016 Oct;23(10):899-905. doi: 10.1038/nsmb.3293. Epub 2016 Sep 12. PMID: 27617430

Role of bacteriophage T4 baseplate in regulating assembly and infection. Yap ML, Klose T, Arisaka F, Speir JA, Veesler D, Fokine A, Rossmann MG. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2654-9. doi: 10.1073/pnas.1601654113. Epub 2016 Feb 29. PMID: 26929357

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Walls AC, Tortorici MA, Bosch BJ, Frenz B, Rottier PJM, DiMaio F, Rey FA, Veesler D. Nature. 2016 Mar 3;531(7592):114-117. doi: 10.1038/nature16988. Epub 2016 Feb 8. PMID: 26855426

Effect of the viral protease on the dynamics of bacteriophage HK97 maturation intermediates characterized by variance analysis of cryo EM particle ensembles. Gong Y, Veesler D, Doerschuk PC, Johnson JE. J Struct Biol. 2016 Mar;193(3):188-195. doi: 10.1016/j.jsb.2015.12.012. Epub 2015 Dec 24. PMID: 26724602

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2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy. Campbell MG, Veesler D, Cheng A, Potter CS, Carragher B. Elife. 2015 Mar 11;4:e06380. doi: 10.7554/eLife.06380. PMID: 25760083

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Near-atomic resolution reconstructions using a mid-range electron microscope operated at 200 kV. Campbell MG, Kearney BM, Cheng A, Potter CS, Johnson JE, Carragher B, Veesler D. J Struct Biol. 2014 Nov;188(2):183-7. doi: 10.1016/j.jsb.2014.09.008. Epub 2014 Sep 30. PMID: 25278130

Single-particle EM reveals plasticity of interactions between the adenovirus penton base and integrin αVβ3. Veesler D, Cupelli K, Burger M, Gräber P, Stehle T, Johnson JE. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8815-9. doi: 10.1073/pnas.1404575111. Epub 2014 Jun 2. PMID: 24889614

Structures and host-adhesion mechanisms of lactococcal siphophages. Spinelli S, Veesler D, Bebeacua C, Cambillau C. Front Microbiol. 2014 Jan 16;5:3. doi: 10.3389/fmicb.2014.00003. eCollection 2014. PMID: 24474948

Distinguishing direct binding interactions from allosteric effects in the protease-HK97 prohead I delta domain complex by amide H/D exchange mass spectrometry. Krishnamurthy S, Veesler D, Khayat R, Snijder J, Huang R, Heck A, Johnson J, Anand GS. Bacteriophage. 2014 Dec 16;4(4):e959816. doi: 10.4161/21597073.2014.959816. eCollection 2014. PMID: 26712354

Architecture of a dsDNA viral capsid in complex with its maturation protease. Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Structure. 2014 Feb 4;22(2):230-7. doi: 10.1016/j.str.2013.11.007. Epub 2013 Dec 19. PMID: 24361271

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Maximizing the potential of electron cryomicroscopy data collected using direct detectors. Veesler D, Campbell MG, Cheng A, Fu CY, Murez Z, Johnson JE, Potter CS, Carragher B. J Struct Biol. 2013 Nov;184(2):193-202. doi: 10.1016/j.jsb.2013.09.003. Epub 2013 Sep 12. PMID: 24036281

Structure, adsorption to host, and infection mechanism of virulent lactococcal phage p2. Bebeacua C, Tremblay D, Farenc C, Chapot-Chartier MP, Sadovskaya I, van Heel M, Veesler D, Moineau S, Cambillau C. J Virol. 2013 Nov;87(22):12302-12. doi: 10.1128/JVI.02033-13. Epub 2013 Sep 11. PMID: 24027307

Cystovirus maturation at atomic resolution. Veesler D, Johnson JE. Structure. 2013 Aug 6;21(8):1266-8. doi: 10.1016/j.str.2013.07.009. PMID: 23931138

Structure and functional analysis of the host recognition device of lactococcal phage tuc2009. Collins B, Bebeacua C, Mahony J, Blangy S, Douillard FP, Veesler D, Cambillau C, van Sinderen D. J Virol. 2013 Aug;87(15):8429-40. doi: 10.1128/JVI.00907-13. Epub 2013 May 22. PMID: 23698314

Viral infection modulation and neutralization by camelid nanobodies. Desmyter A, Farenc C, Mahony J, Spinelli S, Bebeacua C, Blangy S, Veesler D, van Sinderen D, Cambillau C. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1371-9. doi: 10.1073/pnas.1301336110. Epub 2013 Mar 25. PMID: 23530214

Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography. Veesler D, Ng TS, Sendamarai AK, Eilers BJ, Lawrence CM, Lok SM, Young MJ, Johnson JE, Fu CY. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5504-9. doi: 10.1073/pnas.1300601110. Epub 2013 Mar 21. PMID: 23520050

Studying 18 MDa virus assemblies with native mass spectrometry. Snijder J, Rose RJ, Veesler D, Johnson JE, Heck AJ. Angew Chem Int Ed Engl. 2013 Apr 2;52(14):4020-3. doi: 10.1002/anie.201210197. Epub 2013 Feb 28. PMID: 23450509

Visualizing a complete Siphoviridae member by single-particle electron microscopy: the structure of lactococcal phage TP901-1. Bebeacua C, Lai L, Vegge CS, Brøndsted L, van Heel M, Veesler D, Cambillau C. J Virol. 2013 Jan;87(2):1061-8. doi: 10.1128/JVI.02836-12. Epub 2012 Nov 7. PMID: 23135714

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Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N. Structure. 2012 Nov 7;20(11):1823-8. doi: 10.1016/j.str.2012.08.026. Epub 2012 Sep 27. PMID: 23022349

Maturation in action: CryoEM study of a viral capsid caught during expansion. Veesler D, Quispe J, Grigorieff N, Potter CS, Carragher B, Johnson JE. Structure. 2012 Aug 8;20(8):1384-90. doi: 10.1016/j.str.2012.05.011. Epub 2012 Jun 28. PMID: 22748764

Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism. Veesler D, Spinelli S, Mahony J, Lichière J, Blangy S, Bricogne G, Legrand P, Ortiz-Lombardia M, Campanacci V, van Sinderen D, Cambillau C. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8954-8. doi: 10.1073/pnas.1200966109. Epub 2012 May 18. PMID: 22611190

Virus maturation. Veesler D, Johnson JE. Annu Rev Biophys. 2012;41:473-96. doi: 10.1146/annurev-biophys-042910-155407. Epub 2012 Feb 23. PMID: 22404678

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A common evolutionary origin for tailed-bacteriophage functional modules and bacterial machineries. Veesler D, Cambillau C. Microbiol Mol Biol Rev. 2011 Sep;75(3):423-33, first page of table of contents. doi: 10.1128/MMBR.00014-11. PMID: 21885679

Unraveling lactococcal phage baseplate assembly by mass spectrometry. Shepherd DA, Veesler D, Lichière J, Ashcroft AE, Cambillau C. Mol Cell Proteomics. 2011 Sep;10(9):M111.009787. doi: 10.1074/mcp.M111.009787. Epub 2011 Jun 6. PMID: 21646642

The opening of the SPP1 bacteriophage tail, a prevalent mechanism in Gram-positive-infecting siphophages. Goulet A, Lai-Kee-Him J, Veesler D, Auzat I, Robin G, Shepherd DA, Ashcroft AE, Richard E, Lichière J, Tavares P, Cambillau C, Bron P. J Biol Chem. 2011 Jul 15;286(28):25397-405. doi: 10.1074/jbc.M111.243360. Epub 2011 May 26. PMID: 21622577

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Structure and molecular assignment of lactococcal phage TP901-1 baseplate. Bebeacua C, Bron P, Lai L, Vegge CS, Brøndsted L, Spinelli S, Campanacci V, Veesler D, van Heel M, Cambillau C. J Biol Chem. 2010 Dec 10;285(50):39079-86. doi: 10.1074/jbc.M110.175646. Epub 2010 Oct 11. PMID: 20937834

Crystal structure of bacteriophage SPP1 distal tail protein (gp19.1): a baseplate hub paradigm in gram-positive infecting phages. Veesler D, Robin G, Lichière J, Auzat I, Tavares P, Bron P, Campanacci V, Cambillau C.J Biol Chem. 2010 Nov 19;285(47):36666-73. doi: 10.1074/jbc.M110.157529. Epub 2010 Sep 15.PMID: 20843802

Crystal structure of Bacillus subtilis SPP1 phage gp23.1, a putative chaperone. Veesler D, Blangy S, Lichière J, Ortiz-Lombardía M, Tavares P, Campanacci V, Cambillau C. Protein Sci. 2010 Sep;19(9):1812-6. doi: 10.1002/pro.464. PMID: 20665904

Crystal structure of Bacillus subtilis SPP1 phage gp22 shares fold similarity with a domain of lactococcal phage p2 RBP. Veesler D, Blangy S, Spinelli S, Tavares P, Campanacci V, Cambillau C. Protein Sci. 2010 Jul;19(7):1439-43. doi: 10.1002/pro.416. PMID: 20506290

Solution and electron microscopy characterization of lactococcal phage baseplates expressed in Escherichia coli.Campanacci V, Veesler D, Lichière J, Blangy S, Sciara G, Moineau S, van Sinderen D, Bron P, Cambillau C. J Struct Biol. 2010 Oct;172(1):75-84. doi: 10.1016/j.jsb.2010.02.007. Epub 2010 Feb 11. PMID: 20153432

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Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode. Veesler D, Dreier B, Blangy S, Lichière J, Tremblay D, Moineau S, Spinelli S, Tegoni M, Plückthun A, Campanacci V, Cambillau C. J Biol Chem. 2009 Oct 30;284(44):30718-26. doi: 10.1074/jbc.M109.037812. Epub 2009 Sep 9. PMID: 19740746

Production and biophysical characterization of the CorA transporter from Methanosarcina mazei. Veesler D, Blangy S, Siponen M, Vincentelli R, Cambillau C, Sciara G. Anal Biochem. 2009 May 1;388(1):115-21. doi: 10.1016/j.ab.2009.02.018. Epub 2009 Feb 20. PMID: 19233118

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There is a baby in the bath water: AcrB contamination is a major problem in membrane-protein crystallization. Veesler D, Blangy S, Cambillau C, Sciara G.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt 10):880-5. doi: 10.1107/S1744309108028248. Epub 2008 Sep 30.PMID: 18931428

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