Coronavirus spike-mediated membrane fusion
This movie summarizes our current understanding of the process of membrane fusion upon MERS-CoV spike attachment to the dipeptidyl-peptidase 4 host receptor. This mechanism is expected to be similar for other coronaviruses including SARS-CoV-2.
More info can be found here.
SARS-CoV-2 RBD nanoparticle vaccine design
This movie illustrates the design of our clinical-stage protein subunit vaccine displaying the SARS-CoV-2 RBD multivalently at the surface of a self-assembling two component nanoparticle.
More info can be found here.
SARS-CoV-2 RBD nanoparticle vaccine induces neutralizing antibodies
This movie depicts the elicitation of SARS-CoV-2 spike-directed neutralizing antibodies by our clinical-stage protein subunit vaccine, which is believed to be the main mechanism of protection.
More info can be found here.
